• br Funding Sources br Role of

  2018-10-23

  

  Funding Sources Role of Funding Source Conflicts of Interests Author contributions Introduction The effect of disease modifying antirheumatic drugs (DMARDs) in rheumatoid arthritis (RA) on disease activity is generally presented using population means (Combe et al., 2015; Gabay et al.

• br Genetics of Pain Sensitivity Pain is

  2018-10-23

  

  Genetics of Pain Sensitivity Pain is a distressing feeling often caused by unpleasant stimulation resulting in tissue damage, and is the most common reason for general practitioner consultations in the developed world. Geoff Woods (Cambridge, UK) presented the latest developments in the study of

• The utility of newborn TSH

  2018-10-23

  

  The utility of newborn TSH and 17-OHP levels in addition to Hb ratios in model performance was also explored. Similar to hemoglobin, TSH and 17-OHP offer practical advantages as they may be routinely obtained by fluorometric or colorimetric assay rather than by mass spectrometry analysis. These anal

• Infections with eleven species of pathogens associated with

  2018-10-23

  

  Infections with eleven species of pathogens associated with cancers are classified as Group 1 carcinogens, definitely “carcinogenic to humans”, by the IARC. These agents include Helicobacter pylori, hepatitis B virus (HBV), hepatitis C virus (HCV), Opisthorchis viverrini, Clonorchis sinensis, Schist

• Treating Age related Macular Degeneration Using Human iPS Ce

  2018-10-23

  

  Treating Age-related Macular Degeneration Using Human iPS Cells Age-related macular degeneration (AMD) is a medical condition of the eye that results in blurred vision and/or a loss of central vision. The wet form of AMD – caused by abnormal blood vessel growth – is often treated using anti-VEGF me

• br Introduction Oral Oropharyngeal mucositis

  2018-10-23

  

  Introduction Oral/Oropharyngeal mucositis (OM) is probably the most common and debilitating complication that can occur during and shortly after radiotherapy and/or chemotherapy for patients with head-and-neck cancer (HNC). It is typically characterized by: erythema, edema, mucosal ulceration and

• br Conflict of Interest Statement br Author

  2018-10-23

  

  Conflict of Interest Statement Author Contributions N.M., K.N., M.G., R.J.O., and M.K. performed in vitro and in vivo experiments; N.M., H.D., and M.K., performed protein purification, crystallization, data collection, structure determination, and structural analyses; P.C., and J.D.H. carried

• These last few years have seen a shift in

  2018-10-23

  

  These last few years have seen a shift in emphasis from the investigation of individual age-related diseases in isolation toward a broader context to define the basic biology of aging. The concept behind the recently coined pursuit of GeroScience (Burch et al., 2014) is that a strategy to delay the

• Recently several supervised learning methods such as

  2018-10-23

  

  Recently, several supervised learning methods, such as decision trees, have been applied to the analysis of cDNA microarrays to refine prognosis in nasopharyngeal carcinoma, breast cancer and non–small-cell lung cancer.(Chen et al., 2007) State-of-the-art classification algorithms such as support ve

• Reagents Anti HO antibody was purchased

  2018-10-23

  

  Reagents Anti-HO-1 antibody was purchased from Assay Design and R&D systems respectively. Anti-β-actin antibody, heme (hemin) and desferoxamine (DFO), were obtained from Sigma-Aldrich. Hemopexin deficient (HPX−) serum was a kind gift from Dr. EmanualaTolosano, Molecular Biotechnology Center, Univer

• Workflow Mascot Distiller Mascot Skyline MS Signal analysis

  2018-10-23

  

  Workflow 8: Mascot Distiller/Mascot/Skyline/MS Signal analysis. Peaklist creation was performed with Mascot Distiller as described in workflow 3, then database searches were performed with Mascot and validated with Scaffold as described for workflow 4. XIC signal corresponding to all validated pepti

• br Acknowledgements br Value of the data

  2018-10-23

  

  Acknowledgements Value of the data We provide a standard proteomic dataset based on a highly complex sample (yeast lysate) spiked with different levels of a second calibrated protein mixture of medium complexity (UPS1 standard, 48 proteins), that can be used to statistically evaluate label-fre

• br Ethic approval br Acknowledgments This work was supported

  2018-10-23

  

  Ethic approval Acknowledgments This work was supported by the Karlsruhe Institute of Technology (KIT), the Deutsche Forschungsgemeinschaft (DFG Str439/5-1), the Association Française contre les Myopathies (AFM), EU-IP ZF-HEALTH. Data The data shared in this article are the experimental ana

• br Tip distance modelling A steady state convection diffusio

  2018-10-23

  

  Tip distance modelling A steady state convection-diffusion model was fitted to the observed distribution of tip distances, in order to test whether this pattern of attraction and repulsion was sufficient to maintain the cap SIRT1/2 Inhibitor IV in proximity to the ureteric tip. We assume that th

• br Conclusion br Introduction Hydraulic seals are

  2018-10-22

  

  Conclusion Introduction Hydraulic seals are used in a variety of critical applications involving machinery and are several times more expensive compared to seals. The critical importance of the seal can be quantified by the failure of a static O-ring due to cold temperature freezing, causing c

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