• br Acknowledgments We thank Anke Leinhaas and Conny

  2018-10-26

  

  Acknowledgments We thank Anke Leinhaas and Conny Thielen for excellent technical support. We thank the members of the histology laboratory of the Institute of Neuropathology, University of Bonn, for technical assistance with EB and teratoma staining and members of the Stem Cell Engineering Group

• The function of LRRK remains to be fully elucidated

  2018-10-26

  

  The function of LRRK2 remains to be fully elucidated, but studies have demonstrated a role for LRRK2 in neurite elongation and arborization. Cultured dopaminergic neurons from human LRRK2-G2019S-expressing transgenic mice and patient-specific induced pluripotent stem not (iPSCs) display shortened ne

• Finally an important practical implication of

  2018-10-26

  

  Finally, an important practical implication of our data is that both fibroblasts and blood can be used for the generation of comparable iPSC lines for large-scale biobanking purposes (Figure 6). Our results demonstrate that variability among small cohorts of iPSCs may lead to erroneous conclusions (

• Generation of new cells during kidney repair has

  2018-10-26

  

  Generation of new cells during kidney repair has long been assumed to result from proliferation of surviving terminally differentiated cells. However, much of the modern evidence has used lineage tracing such as Six2 (Humphreys et al., 2008) or a terminally differentiated marker (such as the proxima

• The experimental design of this model provides several diffe

  2018-10-26

  

  The experimental design of this model provides several differences to standard 2D culture: EHTs are anchored between two flexible silicone posts, which generate a preload, and EHTs perform auxotonic contractile work (the physiological form of cardiac contraction) against elastic posts. This results

• br Results br Discussion The development of miRNA based

  2018-10-26

  

  Results Discussion The development of miRNA-based therapy approaches has become one of the most attractive areas of tissue engineering (Lian et al., 2012). Recently, many studies reported that miRNAs are important regulators for the therapy or differentiation of stem sphingosine (Cho et al.,

• TSC haploinsufficient astrocytes presented a high proliferat

  2018-10-26

  

  TSC haploinsufficient astrocytes presented a high proliferation rate and an increased saturation density when compared with WT astrocytes. Similarly, the conditional disruption of TSC1 in astrocytes using a human GFAP-Cre system was shown to produce mice that presented with astrocytosis (Han and Sah

• Our results provide information on contributors unique to di

  2018-10-26

  

  Our results provide information on contributors unique to different oral health outcomes, in different countries, and at different times. As identified in our analysis, the contribution of age to inequalities in edentulism may be explained by the inverse relationship between retention of teeth and i

• Tunicamycin The remainder of the paper is organized as follo

  2018-10-26

  

  The remainder of the paper is organized as follows. In Section 2, a review of the literature on the topic is presented. In Section 3, our methodology is explained and some data considerations are added. In Section 4, results are displayed and reflections per gender are offered. Section 5 discusses o

• Broader understanding of pathways of influence could also in

  2018-10-26

  

  Broader understanding of pathways of influence could also inform intervention development. A walking intervention involving the installation of walking route signage and leadership for local walking groups in two low-income neighbourhoods in Ireland had only a marginal effect on physical activity (B

• histone deacetylase inhibitors Prevalence in an immigrant po

  2018-10-26

  

  Prevalence in an immigrant histone deacetylase inhibitors refers to the proportion of girls and women who migrated from the associated practicing country and have already been cut (European Institute for Gender Equality, 2013). Girls at risk of cutting refers to uncut girls aged 18 or younger who mi

• International comparisons are also valuable for studies

  2018-10-26

  

  International comparisons are also valuable for studies evaluating the population-level number of deaths attributable to a behavioral risk factor because these studies often rely on estimates of death risks from the behavioral factor under investigation (Preston & Stokes, 2011; Rostron, 2011). In su

• p2y inhibitor Attended CPAP titration and auto

  2018-10-26

  

  Attended CPAP titration and auto-titrating CPAP provides useful insights regarding the treatment and automated algorithms for detecting IFL, respectively. Condos has shown that rounded inspiratory flow contour with higher CPAP pressures correlates with a lower upper airway resistance. Lower CPAP pre

• br Limitations and strengths There are several limitations t

  2018-10-26

  

  Limitations and strengths There are several limitations to our study. First, sleep-related problems were subjectively measured; therefore, some misclassifications might have occurred. Nonetheless, questions about self-reported sleep problems for timing and duration have demonstrated good validity

• br Materials and methods br Results br

  2018-10-26

  

  Materials and methods Results Discussion This study revealed the optimal conditions required to investigate in vitro epithelial barrier formation using Calu-3 cells, to be used as a screening model for ENM exposure to mimic in vivo conditions. Details on the specific cell line, cell number,

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