A key element of the

2018-10-20

A key element of the culture conditions is the balanced combination of growth factors and signaling molecules (e.g., EGF, bFGF, IGF, insulin, transferrin, and Rock inhibitor), which apparently generates an artificial androgen-independent PESC microenvironment that promotes the self-renewal and maint

Recently several clinical trials of stem cell

2018-10-20

Recently, several clinical trials of stem-cell-based therapy for SCI using either human NS/PCs (Cummings et al., 2005; Salazar et al., 2010) or human ESC-derived OPCs (Strauss, 2010) have been initiated. Compared with these stem cells, iPSCs raise fewer ethical concerns in certain countries (Nori et

br Results br Discussion We

2018-10-20

Results Discussion We have established a novel serum-free culture method for generating and expanding CD271+CD73+SOX9+ chondrogenic ectomesenchymal eicosapentaenoic acid from hPSC-derived, CD271hiCD73− neural crest-like progeny. The differentiation pathways from hPSCs to chondrocytes via chond

br Specification of germ cells in humans

2018-10-20

Specification of germ cells in humans The earliest identification of PGCs in the yolk sac was made by Fuss using transmission electron microscopy (TEM) during week 3 of life (Fig. 1). This work revealed that human PGCs are large spherical cells located amongst the smaller cells of the yolk sac en

c-myc inhibitor Cisplatin and Vorinostat alone produced exci

2018-10-20

Cisplatin and Vorinostat alone produced exciting results, but their combination was extremely efficient in disrupting CSCs and non-CSCs. After 5days of combined therapy, CSCs were completely depleted in HACC2A cells, and a 3.9-fold reduction in CSCs occurred in HACC6 c-myc inhibitor (Fig. 4A and B).

Here we present an algorithm KeyGenes that we

2018-10-20

Here we present an algorithm, KeyGenes, that we have used on NGS data extracted from tissues of 21 different human fetal organs, both embryonic and extraembryonic (plus the maternal endometrium), from the first and second trimesters of development to determine a panel of classifier genes that would

hiv protease In previous tumor studies we have used

2018-10-20

In previous tumor studies, we have used a p53-null syngeneic mouse model to mimic p53 loss of function in human breast cancer. This model was developed by transplanting p53-null mammary epithelium into the cleared mammary fat pads of wild-type, syngeneic Balb/c-recipient mice, resulting in spontaneo

In previous tumor studies we have used

2018-10-20

In previous tumor studies, we have used a p53-null syngeneic mouse model to mimic p53 loss of function in human breast cancer. This model was developed by transplanting p53-null mammary epithelium into the cleared mammary fat pads of wild-type, syngeneic Balb/c-recipient mice, resulting in spontaneo

Our results and analyses suggest that the disorder

2018-10-20

Our results and analyses suggest that the disorder notably disrupts the topology of the network. In the context of the patients, these alterations could significantly affect the normal operation of the brain. Such an aspect is important in the framework of studies that highlight the relation between

We previously discovered that ATM

2018-10-20

We previously discovered that ATM, in addition to serving many roles in cell-cycle regulation and DNA damage response, also functions as a key epigenetic regulator in neurons, likely underlying the ataxic symptoms as well as neurodegeneration. ATM indirectly regulates nuclear-cytoplasmic shuttling o

br Results br Discussion There is considerable interest

2018-10-20

Results Discussion There is considerable interest in developing high-throughput technologies for microscale analysis and screening of both undifferentiated and differentiated human stem/progenitor populations to aid drug screening and toxicity analysis (Bhatia and Ingber, 2014; El-Ali et al.,

This proof of concept study

2018-10-20

This proof-of-concept study showed that the iPSC retina, when transplanted into the eyes of end-stage retinal-degeneration mice, develops a mature ONL and responds to light. Nearly half of the mice with retinal transplant showed light-responsive behavior. We recently showed that the hESC retina can

Hello world!

2018-07-29