• br Results Relying on the high

  2018-10-24

  

  Results Relying on the high conservation of vertebrate TBX3 proteins, we used human TBX3 in murine ESCs due to its specific traceability. We inserted human TBX3 cDNA into the pEF-DEST51 vector (Invitrogen) for EF1α-promoter-based stable and constitutive overexpression in ESCs. Out of 20 independe

• br Experimental Procedures br Acknowledgments br Introductio

  2018-10-24

  

  Experimental Procedures Acknowledgments Introduction Hepatitis C virus (HCV) infects an estimated 2%–3% of the world population and is a major cause of liver disease and cancer. It is estimated that more than 350,000 people die of the HCV-related liver disease each year (Te and Jensen, 2010

• We propose that a quantitative marker

  2018-10-24

  

  We propose that a quantitative marker for tracking cardiac myocyte maturation resides in the developmentally controlled and irreversible (excepting targeted reprogramming) genetic switch in the sarcomeric TNNI gene. Owing to strict developmental control in all mammalian hearts, including humans, the

• It is intriguing that all surviving germ cells

  2018-10-24

  

  It is intriguing that all surviving germ cells in Ret mutant mice expressed GFRA1. It is possible that GFRA1 was upregulated to compensate for the reduction of GDNF signaling. Because of the controversy on GFRA1 expression on SSCs, we performed FACS experiments to explore the relationship between GF

• Since the donor hESC derived cells are allografts

  2018-10-24

  

  Since the donor hESC-derived melanotropin are allografts, there is the possibility of graft rejection after transplantation. Previous allogeneic RPE cell transplantations in dry AMD resulted in graft rejections in some cases, although it started later in the treatment course and was seen less freque

• Although the use of iPSC derived neurons offer a

  2018-10-24

  

  Although the use of iPSC-derived neurons offer a number of advantages because they are human derived and more closely resemble neurons than tumor cell lines, there are some limitations which should be considered (Gurwitz, 2016). They are expensive, do not grow indefinitely and require some level of

• br Results br Discussion Here we describe

  2018-10-24

  

  Results Discussion Here we describe the role for histone demethylases KDM4A and KDM4C in the epigenetic regulation of mESC differentiation to endothelial cells. We showed that KDM4A and KDM4C targeted the tri-methyl histone 3 lysine 9 (H3K9me3), a known repressive marker of gene regulation (Bl

• Many SMs have been reported to facilitate reprogramming

  2018-10-24

  

  Many SMs have been reported to facilitate reprogramming. For example, sodium butyrate (N, NaB), a histone deacetylase (HDAC) inhibitor, greatly improved reprogramming efficiency by upregulating epigenetic remodeling and pluripotency-associated imidazoline receptors (Mali et al., 2010; Zhang and Wu,

• DNA Damage DNA Repair Library Recent studies by our group

  2018-10-24

  

  Recent studies by our group demonstrated the presence of stem DNA Damage DNA Repair Library in the CEP. These cartilage endplate stem cells (CESCs) exhibited superior capacity for chondrogenic and osteogenic differentiation to those of bone marrow mesenchymal stem cells (BM-MSCs) (Liu et al., 2011)

• Recently iPSCs were derived from fibroblasts obtained from

  2018-10-24

  

  Recently, iPSCs were derived from fibroblasts obtained from another unrelated UFM subject (de Esch et al., 2014). The lymphoblastoid cell line from this subject has been previously characterized and showed the same epigenetic profile of the FMR1 promoter-like lymphoblastoid cells from UFM1 (Pietrobo

• br Experimental Procedures br Author Contributions O G perfo

  2018-10-24

  

  Experimental Procedures Author Contributions O.G. performed the analysis, visualization, qRT-PCR, and writing of the manuscript; K.M. carried out Hlf functional experiments; N.B. helped with the computational analysis; Y.G. performed the cell culture and functional assays; M.F. did some of the

• The transient presence of oligodendroblasts

  2018-10-24

  

  The transient presence of oligodendroblasts could also be explained by their progress into full maturation. Intriguingly, we failed to detect fully mature oligodendrocytes generated by oligodendroblasts. This was determined in three ways: first, by the absence of double EYFP+/MBP+ cells; second, by

• br Results The study population that is included is

  2018-10-24

  

  Results The study population that is included is fairly similar to the entire Swedish population born 1934 to 1959 (Table 1). Those who were excluded from the analyses were more likely to be born at the beginning of the period and lack information on the variables of interest, or to be born at th

• While previous studies have analyzed trust from an organizat

  2018-10-24

  

  While previous studies have analyzed trust from an organizational perspective, as well as the role that the leader plays in the creation of a trusting environment, there is currently no consistent theoretical and empirical body of knowledge regarding the study of trust in the leader in virtual setti

• br A tough nut to

  2018-10-23

  

  A tough nut to crack Wicksell\'s (1890) Norwegian article on “Empty stomachs – and full warehouses” was written in June that year in Paris. His visit to France closed the long LDN193189 of economic studies abroad he had started in 1885–1886, which included as well stays in London, Strasbourg, Vi

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