• Introduction Considering the importance of food safety and q

  2018-10-29

  

  Introduction Considering the importance of food safety and quality, more attention is being paid to the health of consumers [1]. However, due to nutrients deficiencies in human societies especially in certain periods of life, embracing, importing, and consumption of fortified foods is increasing [2

• In silico screening systems a combination of focused

  2018-10-29

  

  In silico screening systems, a combination of focused in vitro cell-based models and computer based algorithms employ a variety of different high-throughput and high-content screening technologies. Cell-specific biomarkers on gene, protein or metabolite levels can be measured by toxicogenomics, toxi

• br Results We obtained Institutional Review

  2018-10-29

  

  Results We obtained Institutional Review Board and Embryonic Stem Cell Research Oversight committee approval at the Brigham & Women\'s Hospital and Children\'s Hospital Boston to enroll couples undergoing in vitro fertilization (IVF) in a study for stem cell derivation using donated embryos that

• Since the Rad promoter contains binding

  2018-10-29

  

  Since the Rad51 promoter contains Afatinib for the E2F transcription factor, which is primarily active during entry of cells into S-phase (Bracken et al., 2004; Dyson, 1998; Shirodkar et al., 1992), one might expect that the proportion of the cell cycle spent in S-phase might account in part for th

• One group has recently identified bone marrow BM residing ve

  2018-10-29

  

  One group has recently identified bone marrow (BM)-residing very small embryonic-like stem cells (VSELs) in both human and mouse as a putative nonembryonic source for PSCs (Drukała et al., 2012; Kucia et al., 2006b; Wojakowski et al., 2009; Zuba-Surma et al., 2011). Mouse VSELs have been characteriz

• br Results br Discussion Mammalian primordial germ cells are

  2018-10-29

  

  Results Discussion Mammalian primordial germ hexokinase inhibition are considered unipotent, giving rise only to the gametes. Indeed, the sperm and egg represent two of the most overtly differentiated cell phenotypes. Yet, these two specialized cells regain access to the entire embryonic and

• br Experimental Procedures Drosophila stocks are

  2018-10-29

  

  Experimental Procedures Drosophila stocks are described in the Supplemental Experimental Procedures. Introduction Primitive hematopoietic progenitors arise from the yolk sac in mammals and generate red blood Sulfo-NHS-SS-Biotin (RBCs), thereby providing oxygen to the rapidly developing embryo

• Interestingly Prominin is found in other adult

  2018-10-29

  

  Interestingly, Prominin1 is found in other adult stem cell populations, such as those in the hematopoietic system and small intestine (Snippert et al., 2009; Zhu et al., 2009) and is a marker of tumor-initiating cysteine protease inhibitors in several cancers (Neuzil et al., 2007). It was originall

• br Acknowledgments We thank Anke Leinhaas and Conny

  2018-10-26

  

  Acknowledgments We thank Anke Leinhaas and Conny Thielen for excellent technical support. We thank the members of the histology laboratory of the Institute of Neuropathology, University of Bonn, for technical assistance with EB and teratoma staining and members of the Stem Cell Engineering Group

• The function of LRRK remains to be fully elucidated

  2018-10-26

  

  The function of LRRK2 remains to be fully elucidated, but studies have demonstrated a role for LRRK2 in neurite elongation and arborization. Cultured dopaminergic neurons from human LRRK2-G2019S-expressing transgenic mice and patient-specific induced pluripotent stem not (iPSCs) display shortened ne

• Finally an important practical implication of

  2018-10-26

  

  Finally, an important practical implication of our data is that both fibroblasts and blood can be used for the generation of comparable iPSC lines for large-scale biobanking purposes (Figure 6). Our results demonstrate that variability among small cohorts of iPSCs may lead to erroneous conclusions (

• Generation of new cells during kidney repair has

  2018-10-26

  

  Generation of new cells during kidney repair has long been assumed to result from proliferation of surviving terminally differentiated cells. However, much of the modern evidence has used lineage tracing such as Six2 (Humphreys et al., 2008) or a terminally differentiated marker (such as the proxima

• The experimental design of this model provides several diffe

  2018-10-26

  

  The experimental design of this model provides several differences to standard 2D culture: EHTs are anchored between two flexible silicone posts, which generate a preload, and EHTs perform auxotonic contractile work (the physiological form of cardiac contraction) against elastic posts. This results

• br Results br Discussion The development of miRNA based

  2018-10-26

  

  Results Discussion The development of miRNA-based therapy approaches has become one of the most attractive areas of tissue engineering (Lian et al., 2012). Recently, many studies reported that miRNAs are important regulators for the therapy or differentiation of stem sphingosine (Cho et al.,

• TSC haploinsufficient astrocytes presented a high proliferat

  2018-10-26

  

  TSC haploinsufficient astrocytes presented a high proliferation rate and an increased saturation density when compared with WT astrocytes. Similarly, the conditional disruption of TSC1 in astrocytes using a human GFAP-Cre system was shown to produce mice that presented with astrocytosis (Han and Sah

14986 records 991/1000 page Previous Next First page 上5页 991992993994995 下5页 Last page