• br Funding Sources This project was supported by NIH

  2018-11-05

  

  Funding Sources This project was supported by NIH grants AI081545 (NL) and AI122209 (MS) and BU Pilot Grant (MS). No author received compensation from a pharmaceutical company or other agency for completion of this manuscript. Conflict of Interest Statement Author Contributions Acknowled

• However one might question whether

  2018-11-05

  

  However, one might question whether effective compounds that do not bind to the C-terminal domain of PrP or that have other molecular targets besides PrP () will be excluded from this virtual screening. In the first case, docking with at least the 90–231 domain of the prion protein will prove useful

• The potential uses of technology in providing access to care

  2018-11-05

  

  The potential uses of technology in providing access to care are wide, including in older populations (Ball and Puffett, 1998) as here addressed. In fact, overall, eHealth is becoming an everyday term and is, to various degrees, permeating the lives of many. For instance, in a recent study, Salisbur

• NO is implicated in various other pathological conditions in

  2018-11-05

  

  NO is implicated in various other pathological conditions in the brain, including excitotoxicity during ischemic prostaglandin receptor injury (Nakamura et al., 2013; Pacher et al., 2007). For instance, in the middle cerebral artery occlusion model, the brain injury is milder in mice treated with a

• br Materials and methods br Results

  2018-11-05

  

  Materials and methods Results and discussion Conclusion An RSM based on CCRD and a multi-layer neural network (4-5-1 ANN architecture) models were developed in order to justify the aim of the current research. The input variables were temperature, time, volume of solvent, and particle size,

• Modafinil is a non amphetamine stimulant that

  2018-11-05

  

  Modafinil is a non-amphetamine stimulant that promotes the vigil state, whose mechanism of action is still not fully understood. However, it has been demonstrated that modafinil acts via the blockage of dopamine transporter (DAT) and also the noradrenalin transporter (NET). Besides having these adre

• br Geological setting and sample

  2018-11-05

  

  Geological setting and sample characteristics From South to North, the Tibetan Plateau mainly comprises the Himalaya, Lhasa, Qiangtang, and Songpan-Ganzi Blocks (Yin and Harrison, 2000; Chung et al., 2005) (Fig. 1a). The Himalayan Block lies between the Indian shield to the south and the Indus-Ya

• The pleasure or reward zone of

  2018-11-05

  

  The “pleasure” or “reward” zone of the hypothalamus [13,23–25] is congruent with the site of the greatest concentration of hypocretinergic neurons [26,27]. It is important to consider that, in addition to the hypocretinergic neurons, other groups of neurons such as the melanin concentrating-hormone

• Despite the prevalence of sleep disturbs

  2018-11-05

  

  Despite the prevalence of sleep disturbs be set between elderly individuals without cognitive impairment and dementia patients, the progression of MCI subjects with sleep problems to dementia is still undefined. A longitudinal study that accompanied MCI patients for 10 years conclude, as a major fin

• This study aims to determine if participants

  2018-11-05

  

  This study aims to determine if participants with CFS who, at baseline, are predominantly colonized with gram-positive faecal Streptococcus (determined by stool analysis and suggestive of abnormal gut functioning) will demonstrate significant improvements in sleep (measured by objective actigraphy a

• The Chi squared and Fisher

  2018-11-05

  

  The Chi-squared and Fisher\'s exact hypotheses tests were used for comparing proportions. Poisson regression with robust variance was employed to analyze the factors associated with excess weight (overweight and obesity), allowing identification of both risk and protective factors in qualitative var

• In this paper a study of the

  2018-11-05

  

  In this paper, a study of the differential charge (shielded vs. exposed) on the sense electrodes as a function of MEFM geometry is presented using finite l-name analysis method (FEM). Comparing to the conformal mapping analysis that is commonly used in this area, FEM can more easily deal with a muc

• Antigen Rv is a secretory antigen and a virulence factor

  2018-11-03

  

  Antigen Rv0577 is a secretory antigen and a virulence factor associated with the replication of M. tuberculosis. The antigen is an agonist of Toll-like receptor 2 (TLR2) and can promote maturation of dendritic cells (Byun et al., 2012). Rv2875 encodes a cell membrane-associated antigen, MPT70, of M.

• br Experimental design materials and methods

  2018-11-03

  

  Experimental design, materials and methods Conflict of interest Acknowledgments The authors would like to express their sincere thanks to INATAA Institute and Université Frères Mentouri Constantine for financial support. Authors also thank Dr. Brigitte PICARD and Dr. Ahmed OUALI, INRA Insti

• These following problems are extremely important to TDTCP

  2018-11-03

  

  These following problems are extremely important to TDTCP which uses this type of scheme: accurate and quick prediction of impact point, real time calculation of lateral correction, minimum fire angle with respect to a determined lateral correction, and flight receptor tyrosine kinase criterion anal

14994 records 984/1000 page Previous Next First page 上5页 981982983984985 下5页 Last page