• The Nile tilapia Oreochromis niloticus is an important farme

  2019-09-07

  

  The Nile tilapia (Oreochromis niloticus) is an important farmed fish with an XX/XY sex-determining system. The availability of the whole genome sequence of tilapia and tissue transcriptomes (Brawand et al., 2014), together with its gonadal transcriptomes at different developmental stages (Tao et al.

• Materials and methods br Results

  2019-09-06

  

  Materials and methods Results Discussion Microbial production of trans-4Hyp, an added-value amino pitavastatin for pharmaceuticals, offers significant advantages over conventional chemical extraction in economic and environmental aspects. However the low titer and productivity with the exist

• br Conflict of interest br Acknowledgements This study was s

  2019-09-06

  

  Conflict of interest Acknowledgements This study was supported by the National Natural Science Foundation of China (No.31571839), the Chinese Ministry Program for New Century Excellent Talents in University (NCET-12-0865), and Special Fund for Agro-scientific Research in the Public Interest (N

• br Substrate characterization of candidate

  2019-09-06

  

  Substrate characterization of candidate peptide reporters in a library Measurement of resistance to intracellular proteases Use of capillary zone electrophoresis for assay readout Selection of lead peptide from small library screen Characterization of final reporter Additional modif

• Plasminogen is composed of five

  2019-09-06

  

  Plasminogen is composed of five N-terminal kringle domains and a C-terminal serine protease domain. The kringle domains have an affinity to lysine and binding of plasminogen with its receptors is dependent on its lysine interacting kringle domains [10], [28]. In the current report, we show that enol

• br Conclusions br Declaration of interest

  2019-09-06

  

  Conclusions Declaration of interest Acknowledgements Introduction Uncorrected obesity has been a major health problem and the prevalence of obesity is fast rising reaching an epidemic proportion [[1], [2], [3]]. Ample of clinical and experimental evidence has suggested that obesity leads

• br Materials and methods br Results br Discussion

  2019-09-06

  

  Materials and methods Results Discussion Macrophages and dendritic cells respond to Toll-like receptor (TLR) ligands by upregulating CH25H expression [4], [5]. In the latter cell type TLR-dependent upregulation is mediated via a signalling pathway that involves NFκB and IFNβ secretion and c

• Although our knowledge of the biochemical and biological

  2019-09-06

  

  Although our knowledge of the biochemical and biological functions of E3 ubiquitin ligases has increased in B-cell malignancies, a deeper characterization of cell-context dependent substrate regulation and biological relevance is needed. The recent approval of a general proteasome inhibitor, VELCADE

• In this review focusing on biocatalyst formate dehydrogenase

  2019-09-06

  

  In this review, focusing on biocatalyst “formate dehydrogenase FDH” catalyzing both of the formic Danoprevir oxidation to CO2 and the CO2 reduction to formic acid, representative examples of properties, types, structure of active-site of FDH and, reaction mechanism of formic acid oxidation and CO2

• FAK Inhibitor 14 Introduction The Discoidin Domain Receptors

  2019-09-06

  

  Introduction The Discoidin Domain Receptors (DDRs), comprising DDR1 and DDR2, are collagen-binding receptor tyrosine kinases (RTKs) that function as microenvironmental sensors at the interface of the extracellular matrix and the intracellular signal transduction machinery [1]. In response to ligand

• We thank Dr Hongqiang Qin

  2019-09-06

  

  We thank Dr. Hongqiang Qin at Dalian Institute of Chemical Physics, Chinese Academy of Sciences for technical assistance in mass-spectrometric analysis. We thank Prof. Quentin Liu at Dalian Medical University and Prof. Qiang Shen at M.D. Anderson Cancer Center for helpful discussion and comments. Dr

• Both receptors belong to the

  2019-09-05

  

  Both receptors belong to the large family of G protein-coupled receptors (GPCRs) [4,5], which often appeared as monomers, dimers and higher order aggregates [6,7]. There is evidence that these receptor-complexes can modulate the functionality and the pharmacology of the receptors [8,9] by sequesteri

• br Significance Dysregulation of dopamine homeostasis

  2019-09-05

  

  Significance Dysregulation of dopamine homeostasis contributes to Parkinson\'s disease (PD). The nuclear receptor Nurr1 plays a central role in dopamine homeostasis, regulating the transcription of Enzalutamide governing the synthesis, packaging, and reuptake of dopamine. Efforts to capitalize on

• Although several examples of selective reduction of

  2019-09-05

  

  Although several examples of selective Avasimibe of α-diazoesters to α-hydrazonoesters have been described in the literature, reports on practical and general examples of such a process are scarce. In this context, there was a need to devise a mild and general method for the selective reduction of

• br Introduction Benzanthrone BNZ is a dye intermediate used

  2019-09-05

  

  Introduction Benzanthrone (BNZ) is a dye intermediate used in the synthesis of number of polycyclic vat and disperse dyes. It has been detected as an environmental pollutant in urban ambient air particulates, originating from furnace effluents, municipal refuge, wood and coal combustion and autom

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