• br Conclusion The results of the present study demonstrate t

  2021-01-27

  

  Conclusion The results of the present study demonstrate that cysteinyl leukotrienes LTC4, LTD4 and LTE4 cause moderate to marked whereas the dihydroxy leukotriene LTB4 causes small muscle contraction in the stomach in vitro. The LTD4-induced contraction is mediated by CysLT1 in fundus but by CysL

• The data presented above clearly indicate an important role

  2021-01-27

  

  The data presented above clearly indicate an important role of eIF4E for the nucleocytoplasmic transport of the human iNOS mRNA. To analyze the sequence elements of the iNOS mRNA that are important for this eIF4E-mediated transport we performed transient transfection experiments using constructs con

• The objective of the present study was to investigate the

  2021-01-27

  

  The objective of the present study was to investigate the role of the CRF system in the neuroadaptations associated with nicotine dependence. To this aim, the regulation of the gene expression of CRF and its receptors was assessed in W123 regions belonging to the reward pathway using a model of nic

• Under conditions of energy scarcity or nutritional

  2021-01-27

  

  Under conditions of energy scarcity or nutritional restriction, AMPK, a critical energy sensor, is activated in response to the increased ratio of AMP to ATP. Various kinases may phosphorylate AMPK, leading to its activation. For example, AMPK phosphorylation by liver kinase B 1 (LKB1) at Thr172 res

• Due to the results of the experiment we decided

  2021-01-27

  

  Due to the results of the experiment we decided to deploy our cloud service infrastructure with two platform-independent servers instead of one or three. This decision was based on two factors: (a) the use of more than one server is useful to avoid a bottleneck in the system, and (b) using more than

• br Methods br Results IAA abrogated the protective

  2021-01-27

  

  Methods Results IAA-94 abrogated the protective effects of IPC as it increased myocardial infarction (MI) due to IR injury in vitro (Diaz et al., 1999), and also prevented cyclosporine A mediated cardioprotection (Diaz et al., 2013). Moreover, IAA-94-sensitive currents were observed in cardiac

• br Materials and methods br Results br Discussion The phosph

  2021-01-26

  

  Materials and methods Results Discussion The phosphatidylinositol 3-kinase-like protein kinases, ATM, ATR, and DNA-PK, have all been implicated in H2AX phosphorylation in response to different stimuli [37], [41], [42], [43], [44], [45]. We show here that H2AX is phosphorylated in rodent and

• Patients with a tumor of cm or greater were

  2021-01-26

  

  Patients with a tumor of 4 cm or greater were more likely to have lymph node or tumor metastasis (Fisher’s test p = 0.0001 and 0.0003, respectively). In this smaller patient group a significant correlation between higher DAPK-1 mRNA Z-IETD-FMK receptor in tumor and normal tissue in tumor-free patien

• br Materials and methods br Acknowledgments This research wa

  2021-01-26

  

  Materials and methods Acknowledgments This research was supported by funding from University of California Irvine to H.U.B. Introduction Oral squamous cell carcinoma (OSCC) is the fourth major cause of mortality among men in Taiwan and its incidence rates continue to rise annually. OSCC is

• The ACC receptor family appear to be attractive

  2021-01-26

  

  The ACC receptor family appear to be attractive targets for the development of novel anthelmintics. With this in mind we also tested the activity of the anthelmintics levamisole and pyrantel which activate the nematode nAChR (Martin and Robertson, 2007). We found both molecules were partial agonists

• To further investigate mechanisms of rXCI we generated femal

  2021-01-26

  

  To further investigate mechanisms of rXCI, we generated female ESCs with a homozygous RlimKO. We found that these AZD1390 receptor undergo XCI in vivo but that XCI in vitro is strongly influenced by culture conditions, including both method of differentiation and O2 levels. Our results demonstrate

• Introduction Hematopoietic stem cells HSCs in the adult

  2021-01-26

  

  Introduction Hematopoietic stem ddhC (HSCs) in the adult bone marrow (BM) provide all types of blood cells throughout life, while also self-renewing to maintain blood homeostasis. Blood/marrow stem cell transplantation is the most advanced method to cure patients suffering from hematological malig

• Early tubular differentiation in WT lacks lumen formation an

  2021-01-26

  

  Early tubular differentiation in WT lacks lumen formation and, therefore, sometimes can be confused with rosettes of ES/PNET or neuroblastoma. However, tubular structure usually has Guvacoline hydrobromide neatly aligned to form a single layer around the future lumen, whereas neuroblastic rosettes

• Furan analogs and N methylpyrrole analogs had completely

  2021-01-26

  

  Furan analogs and N-methylpyrrole analogs had completely different SARs. For example, replacement of the furan-2-sulfonyl moiety of 6 with the furan-3-sulfonyl moiety resulted in 8 with a decreased EP1 Conoidin A affinity and an increased antagonist activity, while the corresponding chemical modifi

• br Cytochrome P monooxygenases Cytochrome

  2021-01-26

  

  Cytochrome P450 monooxygenases Cytochrome P450 monooxygenases (P450s) belong to one of Nature’s most versatile group of enzymes for C–H functionalization and are able to perform challenging regioselective and stereoselective activations of remote, unactivated C(sp3)–H bonds, for which there are o

15766 records 684/1052 page Previous Next First page 上5页 681682683684685 下5页 Last page