• Since the beginning of s

  2024-04-03

  

  Since the beginning of 1990s, more than 17,000 papers about physiological relevance of antioxidants have been published according to data from web of science. Based on the available literature, it seems that assessing the antioxidant potential of food by means of in vitro assays or solely epidemiolo

• br Acknowledgments br Protein microarrays were developed

  2024-04-03

  

  Acknowledgments Protein microarrays were developed to provide miniaturized high-throughput tools to study protein function, Cy7 NHS ester (non-sulfonated) and post-translational modifications. Just a few years ago, the seminal work performed in Stuart Schreiber's laboratory at Harvard Universi

• Thiazole heterocycles constitute an interesting

  2024-04-03

  

  Thiazole heterocycles constitute an interesting class of molecules, which exhibit a broad spectrum of biological activity, including antifungal properties [[16], [17], [18], [19]]. Encouraged by our previous study that describes the activity of hydrazine-thiazole derivatives against C. gattii and C.

• Most clinically approved antiangiogenic drugs are

  2024-04-03

  

  Most clinically approved antiangiogenic drugs are aimed at blocking the action of vascular endothelial growth factor, or VEGF, which is accepted to be the most important tumor-derived angiogenic factor, stimulating proliferation and migration of endothelial cells, as well as branching of vessels (Fe

• CHC br Role of AR in models

  2024-04-03

  

  Role of AR in models of neointima formation Investigations into the pathogenesis of lesion formation have often used acute models of mechanical damage to assess the mechanisms regulating the fibro-proliferative response to arterial injury. Models of acute injury used for this purpose include: lig

• br Discussion The present understanding is that patients suf

  2024-04-03

  

  Discussion The present understanding is that patients suffering from AD are at a higher risk for epilepsy than individuals without AD [[1], [2]]. The clinical diagnostic accuracy of AD has improved significantly during the last decades. However, most of the epidemiological studies on these two of

• prostaglandin receptor ADORs accomplish a variety of

  2024-04-02

  

  ADORs accomplish a variety of physiological effects in different tissues. In neurons, ADORs regulate the release of neurotransmitters such as dopamine and glutamate (Ferré et al., 1992; Fredholm and Dunwiddie, 1988; Ginsborg and Hirst, 1972; Gonçalves et al., 2015; Quarta et al., 2004; Stella et al.

• br Conclusions Several lines of evidence have been establish

  2024-04-02

  

  Conclusions Several lines of evidence have been established, which support the adenosine kinase hypothesis of epileptogenesis, which is based on a sequence of events leading from acute Pyocyanin injury to initial downregulation of ADK, rise in extracellular adenosine, changes in astrocytic adeno

• br Conclusions Several lines of evidence have been establish

  2024-04-02

  

  Conclusions Several lines of evidence have been established, which support the adenosine kinase hypothesis of epileptogenesis, which is based on a sequence of events leading from acute parp inhibitors injury to initial downregulation of ADK, rise in extracellular adenosine, changes in astrocytic

• By applying each external load to

  2024-04-02

  

  By applying each external load to the G-actin molecule, and measuring the elongation of the molecule, we computed force-displacement curves. The force versus displacement curve can be used to evaluate the tensile stiffness of the G-actin from a linear regression analysis. Followed by statistical ana

• Osteocytes the most abundant cells in an adult

  2024-04-02

  

  Osteocytes, the most abundant cells in an adult skeleton, are essentially mature osteoblasts that are surrounded by the products they secreted (Noble and Reeve, 2000). Osteocytes serve as mechanosensors that direct bone remodeling and that regulate the activities of osteoblasts and osteoclasts (Bone

• br LOX in esophageal cancer Various studies suggest that abn

  2024-04-02

  

  5-LOX in esophageal cancer Various studies suggest that abnormal levels of AA metabolites play an essential role in human esophageal adenocarcinogenesis (EAC). The key AA derivatives of 5-LOX signaling molecules namely include, 5-HETE, LTB4, and cysteinyl LTs, which are well-known to initiate inf

• br Dual role of autophagy in human diseases Emerging

  2024-04-02

  

  Dual role of autophagy in human diseases Emerging evidence suggests that autophagy serves as a double-edged sword in several human diseases, such as CNS diseases (Rubinsztein et al., 2015), arteriosclerosis (Schrijvers et al., 2011) and cancer (Ozpolat and Benbrook, 2015). Likewise, currently the

• br Materials and methods br Results br

  2024-04-02

  

  Materials and methods Results Discussions Our results indicated that autophagy was suppressed in GECs under HAGG treatment, through Akt/mTOR-dependent pathways. Previous reports provided clues for the linkages between ICs and endothelial cell autophagy. Fujii and colleagues reported that se

• br Experimental section br Competing interests br Author s c

  2024-04-02

  

  Experimental section Competing interests Author's contributions Acknowledgement This research is partially supported by a seed fund for the Center for Drug Discovery and Translational Research (LS) and a research grant by Fujifilm (VPS and LS). The Sponsors played no roles in study desig

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